Alterations in D-Type Cyclins and p27 Osteoclast Precursors via Akt-Dependent SHIP1 Negatively Regulates Proliferation of
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Src regulates cell cycle protein expression and renal epithelial cell proliferation via PI3K/Akt signaling-dependent and -independent mechanisms.
Our recent studies showed that Src family kinases (SFKs) are important mediators of proliferation in renal proximal tubular cells (RPTC). In this study, we elucidate the signaling mechanisms that mediate SFK regulation of cell proliferation and cycle protein expression, and identify the SFK member responsible for these responses in a mouse RPTC line. Akt, a target of phosphoinositide-3-kinase (...
متن کاملبررسی متیلاسیون راهانداز p27Kip1 در بیماران مبتلا به کولیت اولسرو
Background & Aims: The CDK inhibitor (CDKI) protein p27kip1 (p27) negatively regulates cyclin D–CDK4 complex in the G1 phase. Alterations in the expression of p27 kip1 cause a degradation of cell growth and promote the development of various diseases. Aberrant methylation patterns have been reported in large number of diseases. The purpose of this study was to investigate the methylation ...
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Thyroid hormone regulates early postnatal Sertoli cell proliferation. Transient neonatal hypothyroidism allows prolonged postnatal Sertoli cell mitogenesis and doubles adult Sertoli cell numbers, testis weight, and sperm production. The mechanism of this effect is unknown. Cell proliferation is stimulated by cyclins and cyclin-dependent kinases and inhibited by cyclin-dependent kinase inhibitor...
متن کاملT Cell-Intrinsic and Extrinsic Mechanisms of p27Kip1 in the Regulation of CD8 T Cell Memory
CD8 T cells exhibit dynamic alterations in proliferation and apoptosis during various phases of the CD8 T-cell response, but the mechanisms that regulate cellular proliferation from the standpoint of CD8 T-cell memory are not well defined. The cyclin-dependent kinase inhibitor p27(Kip1) functions as a negative regulator of the cell cycle in T cells, and it has been implicated in regulating cell...
متن کاملNon-T cell activation linker promotes mast cell survival by dampening the recruitment of SHIP1 by linker for activation of T cells.
The linker for activation of T cells (LAT) and the non-T cell activation linker (NTAL) are two transmembrane adapters which organize IgE receptor (FcepsilonRI) signaling complexes in mast cells. LAT positively regulates, whereas NTAL negatively regulates mast cell activation. We previously found that the four distal tyrosines of LAT can generate negative signals. We show here that two of these ...
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